This invention relates to improved methods of inducing an immune response
for the prevention or treatment of HIV-1 infection by using a nucleic
acid vaccine in conjunction with a recombinant viral vaccine, e.g., a
poxvirus vaccine, to potentiate and broaden the immune response. The
present invention further provides a particularly effective vaccine
regimen comprising a DNA vaccine used in combination with a poxvirus
virus, especially NYVAC or ALVAC.