A method and apparatus for treatment of skin or other tissue, using a
source of thermal, electromagnetic radiation, electrical current,
ultrasonic, mechanical or other type of energy, to cause
minimally-invasive thermally-mediated effects in skin or other tissue
which stimulates a wound-healing response, in conjunction with topical
agents or other wound healing compositions, for application on the skin
or other tissue which accelerate collagenesis, such as in response to
wound healing. The dosage and time period of application of the
compositions are adjusted to prevent external or surface tissue damage.