The present invention relates to a method of preventing modification of a synthetic oligonucleotide or oligonucleotide analog during removal of at least one cyanoethyl protecting group from the oligonucleotide or oligonucleotide analog. The method involves contacting the oligonucleotide or oligonucleotide analog with a basic solution having at least one acrylonitrile scavenger, such as t-butylamine, at a sufficient temperature and for a sufficient period of time to remove at least one .beta.-cyanoethyl protecting group. The present invention also relates to a method of producing a synthetic oligonucleotide or oligonucleotide analog.

 
Web www.patentalert.com

< Neisseria meningitidis antigenic polypeptides, corresponding polynucleotides and protective antibodies

< Novel steroid/thyroid hormone receptor-related gene, which is inappropriately expressed in human heptocellular carcinoma, and which is a retinoic acid receptor

> Indolopyrrolocabazole derivative and antitumor agent

> Nucleotide sequences encoding RAMOSA3 and sister of RAMOSA3 and methods of use for same
~ 00285