PDE4 inhibition is achieved by novel nitroxide compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formulas I-III: wherein A, B, D, R.sup.1, R.sup.2, R.sup.3, R.sup.7, R.sup.8, R.sup.9, R.sup.10 and R.sup.6 are as defined herein.

 
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