This invention concerns a compound of formula ##STR00001## a N-oxide, a
pharmaceutically acceptable addition salt, a quaternary amine and a
stereochemically isomeric form thereof, wherein R.sup.1 is hydrogen,
hydroxy, cyano, amino, mono-or di(C.sub.1-4alkyl)amino, formyl, carboxyl,
C.sub.1-6alkyl, hydroxyC.sub.1-6alkyl, polyhaloC.sub.1-6alkyl,
C.sub.2-6alkenyl, C.sub.2-6alkynyl, C.sub.3-7cycloalkyl,
C.sub.1-6alkyloxy, C.sub.1-6alkylcarbonyl, aminocarbonyl,
--S(.dbd.O).sub.m--NH.sub.2, mono-or di(C.sub.1-4alkyl)aminocarbonyl,
C.sub.1-6alkyloxycarbonyl, C.sub.1-6alkylcarbonyloxy, aryl,
arylC.sub.1-6alkyl or aryloxy; R.sup.2 is hydrogen; halo; mercapto;
formyl; cyano; carboxy; azido; hydroxy; oxiranyl; amino; mono- or
di(C.sub.1-4alkyl)amino; formylamino; R.sup.5R.sup.6N--C(.dbd.O)--;
R.sup.7--N.dbd.C(R.sup.8)--; C.sub.1-6alkyl-S(.dbd.O)m;
aryl-S(.dbd.O).sub.m; optionally substituted C.sub.2-6alkenyl; optionally
substituted C.sub.2-6alkynyl; C.sub.1-6alkyloxy;
hydroxyC.sub.1-6alkyloxy; aminoC.sub.1-6alkyloxy; mono- or
di(C.sub.1-4alkyl)amino-C.sub.1-6alkyloxy; C.sub.1-6alkylcarbonyl;
arylcarbonyl; Het.sup.1carbonyl; C.sub.1-6alkyloxycarbonyl;
C.sub.1-6alkylcarbonyloxy; aryl; aryloxy; arylC.sub.1-6alkyloxy;
arylthio; arylC.sub.1-6alkylthio; mono- or di(aryl)amino; Het.sup.1;
Het.sup.1oxy; Het.sup.1thio; Het.sup.1C.sub.1-6alkyloxy;
Het.sup.1C.sub.1-6alkylthio; mono- or di(Het.sup.1)amino;
C.sub.3-7cycloalkyl; C.sub.3-7cycloalkyloxy; C.sub.3-7cycloalkylthio;
C.sub.1-6alkylthio; hydroxyC.sub.1-6alkylthio; aminoC.sub.1-6alkylthio;
mono- or di(C.sub.1-4alkyl)aminoC.sub.1-6alkylthio; optionally
substituted C.sub.1-6alkyl; R.sup.3 or R.sup.4 each independently
represent optionally be substituted phenyl, pyridyl, pyrimidinyl,
pyrazinyl or pyridazinyl; --X-- is a bivalent radical selected from
--NR.sup.14--, --NH--NH--, --N.dbd.N--, --O--, --C.sub.1-6alkanediyl-,
--C(.dbd.O)--, --CHOH--, --S--, --S(.dbd.O).sub.m--; aryl is optionally
substituted phenyl; Het.sup.1, Het.sup.2 or Het.sup.3 represent an
optionally substituted monocyclic or bicyclic heterocycle; their use as a
medicine, their processes for preparation and pharmaceutical compositions
comprising them.
