An apparatus and method for subsequent optimization of radiosurgery and
radiotherapy is provided. The invention includes administering a
metalloporphyrin to the patient, and then creating a 3-dimensional
mapping of tissue through use of PET or SPECT. Malignant and
pre-malignant tissue has an affinity for the metalloporphyrin. During
treatment, real-time images are also provided which are compared to the
previous 3-dimensional mapping. Creation of the real-time images is also
achieved through PET or SPECT wherein a metalloporphyrin is administered
to the patient. Total administration of radiation is calculated by
summing radiation from the metalloporphyrins and from the
radiosurgery/radiotherapy. The amount of radiation delivered by the
metalloporphyrins and by the radiosurgery/radiotherapy are adjustable
based on a patient's response to the dual delivery.