The present invention relates to a method of detection of an early-stage
renal disease, comprising determining the concentration of human
lipocalin-type prostaglandin D synthase in a body fluid sample taken from
a subject and comparing the determined concentration with a reference
value set by determining the concentrations of human lipocalin-type
prostaglandin D synthase in body fluid samples taken from healthy
subjects; and a method of disease state management for a renal disease,
comprising determining the concentration of human lipocalin-type
prostaglandin D synthase in a body fluid sample taken from a subject and
evaluating the glomerular filtration ability of the subject from the
determined concentration.