The present invention relates to Ca.sup.2+ channel blockers and more particularly to the R-type Ca.sup.2+ channel blockers. More specifically, the invention relates to Ca.sup.2+ channel blockers activity of Mandevilla velutina and Mandevilla illustris. The present invention further concerns saponin-like compounds isolated from Mandevilla species. The present invention also relates to the treatment of several pathologies that involve the nifedipine-insensitive but isradipine sensitive steady-state R-type Ca.sup.2+ channel and the use of steady-state R-type Ca.sup.2+ channel blockers in the treatment of these pathologies.

 
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