Methods and compounds for reversing pathological vasodilation of blood
vessels, for example vasodilation caused by activation of CB1-like
receptors, by administering to a subject a therapeutically effective
amount of a compound sufficient to induce vasoconstriction, the compound
comprising: ##STR00001## wherein dashed lines independently represent
either a single or a double bond, R.sub.1 is a lower alkyl, R.sub.2 is a
lower alkyl, R.sub.3 is a lower alkyl or halogen, R.sub.4 is a lower
alkyl or hydrogen, R.sub.5 is a lower alkyl or hydrogen, R.sub.6 is a
hydrogen, lower alkyl or halogen, and R.sub.7 is a hydrogen, lower alkyl
or halogen. The vasoconstrictor can be used for a variety of purposes,
including hemostasis or the treatment of shock, for example vasodilatory
shock syndromes such as septic shock.