A method and system may be provided to perform a process for controlling a target system. In one aspect of the invention, the process may include determining a design space (D8) including a first set of control data values associated with a set of control variables (X). A model (800) may be generated that reflects a relationship between the first set of control data values and a first set of response data values associated with a set of response variables (Y). Further, the process may test the model (800) to determine whether a set of predicted response data values associated with the set of response variables (Y) meets a predetermined criteria based on a set of actual response data values associated with the set of response variables (Y). The design space (D8) may then be modified to obtain a relationship between a second set of control data values associated with the set of control variables and a second set of response data values associated with the set of response variables, and the second set of control data values may then be applied to the target system.