The invention relates to a process for the preparation of racemic
citalopram free base or an acid addition salt thereof and/or R- or
S-citalopram as the free base or an acid addition salt thereof by
separation of a mixture of R- and S-citalopram with more than 50% of one
of the enantiomers into a fraction consisting of racemic citalopram
and/or a fraction of S-citalopram or R-citalopram characterized in that
i) citalopram is precipitated from a solvent as the free base or as an
acid addition salt thereof; ii) the precipitate formed is separated from
the mother liquor; iia) if the precipitate is crystalline it is
optionally recrystallised one or more times to form racemic citalopram,
and then optionally converted into an acid addition salt thereof; iib) if
the precipitate is not crystalline, steps i) and ii) are optionally
repeated until a crystalline precipitate is obtained and the crystalline
precipitate is recrystallised one or more times to form racemic
citalopram, and then optionally converted into an acid addition salt
thereof; iii) the mother liquor is optionally subjected to further
purification and S-citalopram or R-citalopram is isolated from the mother
liquor and optionally converted into an addition salt thereof.