The present invention relates to a compound of the formula 1 ##STR00001##
wherein R.sup.1 R.sup.4 are as defined herein. Such novel pyrimidine
derivatives are useful in the treatment of abnormal cell growth, such as
cancer, in mammals. This invention also relates to a method of using such
compounds in the treatment of abnormal cell growth in mammals, especially
humans, and to pharmaceutical compositions containing such compounds.