A drive of a variable valve lift mechanism for driving a control shaft controlling a variable valve lift mechanism provided between an engine valve and an engine valve operating cam in order to change lift amount of the engine valve, comprises: a rotational force generating actuator; power conversion means for converting a rotational force of the rotational force generating actuator into a pivoting force of the control shaft; and a casing containing the power conversion means with the rotational force generating actuator coupled to an outer face of the casing. One end of the control shaft protrudes outward from one side of an engine body. The casing into which one end of the control shaft is inserted is attached to the one side of the engine body through fixing means which can be repeatedly attached and detached. Thus, it is possible to avoid the engine body from being complex and improve maintainability.