The invention relates to a new kind of human protein associated with hepatoma and the polynucleotide encoding the polypeptide and a process for producing the polypeptide by recombinant methods. The present invention also relates to a method of applying the polypeptide for the diagnosis and treatment of various kinds of disease, such as cancer. Further, present invention relates to the antagonist of the polypeptide and therapeutic use of the same. In addition, the invention relates to the use of the same. In addition, the invention relates to the use of polynucleotide encoding the hepatoma associated human protein.