This invention relates to compounds, compositions, and methods useful for
modulating VEGF and/or VEGFR gene expression using short interfering
nucleic acid (siNA) molecules. This invention also relates to compounds,
compositions, and methods useful for modulating the expression and
activity of other genes involved in pathways of VEGF and/or VEGFR gene
expression and/or activity by RNA interference (RNAi) using small nucleic
acid molecules. In particular, the instant invention features small
nucleic acid molecules, such as short interfering nucleic acid (siNA),
short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA
(miRNA), and short hairpin RNA (shRNA) molecules and methods used to
modulate the expression of VEGF and/or VEGFR genes. The application also
relates to methods of treating diseases and conditions associated with
VEGF and/or VEGFR gene expression, such as ocular diseases and
conditions, including age related macular degeneration (AMD) and diabetic
retinopathy, as well as providing dosing regimens and treatment
protocols.