At least one of the multiple process parameters (MPPs) is a controllable process parameter (CTPP) and one is a targeted process parameter (TPP). The process also has a defined target limit (DTV) representing a first limit on an actual average value (AAV) of the TPP. A first logical controller predicts future average values (FAVs) of the TPP based on the AAVs of the TPP over a first prior time period and the DTV. A second logical controller establishes a further target limit (FTV) representing a second limit on the AAV of the TPP based on one or more of the predicted FAVs, and also determines a target set point for each CTPP based on the AAVs of the TPP over a prior time period and the FTV. The second logical controller directs control of each CTPP in accordance with the determined target set point.