The present invention relates to a novel human peroxisome proliferator activated receptor, hPPAR.gamma.. hPPAR.gamma. differs from the mouse peroxisome proliferator activated receptor .gamma. in the nucleotide sequence and the amino acid sequence. The invention provides isolated, purified, enriched or recombinant nucleic acid encoding hPPAR.gamma. polypeptides and vectors containing thereof, cells transformed with such vectors, and methods of screening for agonists and antagonists of hPPAR.gamma. polypeptides. The invention also provides isolated, purified, enriched, or recombinant hPPAR.gamma. polypeptides, antibodies having specific binding affinity to hPPAR.gamma. polypeptides, and hybridomas producing such antibodies.

 
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