A system and method of identifying patients with an increased risk for medication misuse as a result of their physical condition or inability to follow a prescription drug regimen. This is accomplished by an onsite evaluation of the patient, their physical condition and medication usage, including prescriptions, over the counter medications, herbals and food interactions, by a qualified individual. The results of this evaluation are provided to a database that generates a report comprising a patient's vital signs, medication interactions, prescription changes, prescription renewals, discontinued medications, evaluation of a patient's compliance with their medication regimen and education approved for to assist the patient with their compliance for review by the patient's primary care physician, additional physicians treating the patient, authorized organizations, such as HMOs, gardians or other authorized individual. With this knowledge the physician can identify a current or potential problem and can recommend changes to a patient's prescription drug regimen or education regarding drug regimens to correct the problem.