Disclosed are novel compounds of the formula: and the pharmaceutically
acceptable salts and solvates thereof. Examples of groups comprising
Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl,
aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups
comprising Substituent B include aryl and heteroaryl. Also disclosed is a
method of treating a chemokine mediated diseases, such as, cancer,
angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple
sclerosis, rheumatoid arthritis, osteoarthritis, stroke and ischemia
reperfusion injury, pain (e.g., acute pain, acute and chronic
inflammatory pain, and neuropathic pain) using a compound of formula IA.