Methods of using a guide catheter employ a retractable inner guide movably disposed within an open lumen of a splittable outer guide. The outer guide includes a longitudinal pre-stress line extending from distal to proximal ends. The inner guide includes an open lumen adapted to receive a payload. The inner guide is translatable and rotatable relative to the outer guide. The guide catheter further includes a proximally attached guide handle which is separable into at least two sections. Separation of the guide handle splits the proximal end of the outer guide. Proximal outer guide retraction continues the splitting of the outer guide along the longitudinal pre-stress line.