Certain embodiments of the present invention provide a system and method for interpreting images. An image acquisition device, such as a computerized tomography (CT) system, an ultrasound system, an electron beam tomography (EBT) system, a magnetic resonance (MR) system and the like, generates images and image sets, including a first image set and a second image set. A user may select notable images from the first image as significant images. Image content registration software identifies the contents of the significant images and the contents of the second image set. The contents may be anatomical contents. The contents of the significant images are compared to the contents of the second image set. Images from the second image set having contents corresponding to contents of the significant images are selected as preferred images. The preferred images may be labeled and displayed to a user.