A multi-part single-use toothbrush system includes an electric toothbrush such as a rotary electric toothbrush, a plurality of disposable toothbrush heads, some with one or more tooth-cleaning/preserving substances sufficient for a single use, and each with a connector for attachment to and detachment from the electric toothbrush, a dispenser for holding and dispensing such disposable toothbrush heads, and a plurality of sealed single use capsules each containing a brush head and one or more tooth-cleaning/preserving substances.