A tamper-resistant RFID wristband that becomes permanently disabled upon tampering. The wristband includes a plurality of holes for snugly securing the band to a wearer, an RFID circuit, and an electrically conductive loop disposed in the band. The RFID circuit and the conductive loop are electrically coupled to form a series circuit, severance of which disables the wristband. The electrically conductive loop includes a first layer and a second layer that are electrically isolated from one another, save for at least one electrical connection made preferably by a via at the end of the band distal from the antenna element. The first layer encircles the holes in a serpentine path on one layer of the band and the second layer encircles the holes in a complimentary serpentine path on a different layer of the band.