Methods for providing practical magnetic resonance imaging systems that
utilize non-homogeneous background fields, B.sub.0, as well as, possibly
non-linear, gradient fields G.sub.1, G.sub.2 to make non-invasive
measurements to determine, among other things, a spin density function.
These methods are time and SAR efficient, using one or two refocusing
pulses for each line measured in k-space. Two types of non-homogeneous
background fields are considered: background fields B.sub.0 in which the
function |B.sub.0| does not have a critical point within the field of
view, and background fields B.sub.0 such that the function |B.sub.0| has
a single critical point within the field of view. In the first case, an
MR-imaging device may be constructed by using the permanent gradient in
the background field, B.sub.0, as a slice select gradient, so long as
particular criteria are met. The methods demonstrate that there are many
practical circumstances where these criteria can all be met. An apparatus
meeting such criteria can allow one to make non-invasive measurements
that allow a reconstruction of the spin density function determined by a
3-dimensional object. The measurement process using such an apparatus
includes the steps of placing the object to be imaged in an inhomogeneous
background field B.sub.0 for a sufficient time for the nuclear spins of a
desired species to be polarized, selectively exciting the polarized
nuclear spins using standard selective excitation RF-pulse sequences from
apparatus that generates substantially homogeneous RF-fields within a
field of view of the apparatus, and spatially encoding phases of the
excited nuclear spins using gradient fields G.sub.1, G.sub.2, where the
functions |B.sub.0|, ,
define coordinates within the field of view of the apparatus. Also, under
these same assumptions on the magnetic fields, one can use a combination
of the fields B.sub.0, G.sub.1, and G.sub.2 to define a slice select
direction not parallel to the permanent gradient in B.sub.0 In this case
one recovers a 2D-imaging protocol, using an inhomogeneous background
field, with most of the features of standard spin-warp imaging. In the
second case, magnets may be constructed so that |B.sub.0| has an isolated
non-zero local minimum. Using selective excitation, one can excite only
the spins lying in a small neighborhood of this local minimum. In this
way one can do spatially localized, high SNR, spectroscopic measurements,
without any need for further spatial encoding.