The present invention is for novel compositions and methods for treating
cancer, particularly, for treating cancer in mammals and more
particularly in humans. The therapeutic compositions of the present
invention include liposome entrapped irinotecan in which the liposome can
contain any of a variety of neutral or charged liposome-forming compounds
and cardiolipin. The liposomes of the present invention can be either
multilamellar vesicles and unilamellar vesicles, as desired.