A computer interactive isometric exercise system includes an effector, a sensor coupled at a selected location on the effector to measure a force applied by a user to the effector, where the applied force effects a strain on the effector, and control circuitry. The control circuitry includes a processor that receives and processes data corresponding to applied force information measured by the sensor for transference to a host computer. The processed data is transferred in a format compatible with the host computer and facilitates user interaction with the host computer in response to effector manipulation by the user. A plurality of effectors may further be combined together to form a system frame that provides a variety of isometric exercises for the user in combination with user interaction with the host computer.