The invention relates to the use in the preparation of medicines having
activity of the antihypertensive type, useful for treating or preventing
hypertension, of one or more peptides having inhibiting activity on ACE
with IC.sub.50 values of the order of or less than 60 .mu.M, selected
from the group of peptides having the following amino acid sequences:
TABLE-US-00001
Thr-Val-Tyr (SEQ ID No.: 1)
Asn-Met-Ala-Ile-Asn-Pro-Ser-Lys (SEQ ID No.: 2)
Phe-Ala-Leu-Pro-Gln-Tyr (SEQ ID No.: 3)
Phe-Pro-Gln-Tyr-Leu-Gln-Tyr (SEQ ID No.: 4)
Phe-Ala-Leu-Pro-Gln-Tyr-Leu-Lys (SEQ ID No.: 5)
Asn-Met-Ala-Ile-Asn-Pro (SEQ ID No.: 6)
Phe-Ala-Leu-Pro. (SEQ ID No.: 7)
The invention also relates to a pharmaceutical composition containing as
its active principle an effective quantity of one or more of the
above-cited peptides in combination with a pharmaceutically acceptable
vehicle. The invention also relates to a food product, in particular
suitable for supplementing the diet of people subject to hypertension or
seeking to prevent the appearance thereof, containing an effective
quantity of one or more of the above-cited peptides, in combination with
food supports, in particular proteins, lipids, or carbohydrates. Such a
food product may also include at least one of the peptides having the
following amino acid sequences:
TABLE-US-00002
Ala-Leu-Asn-Glu-Ile-Asn-Gln-Phe- (SEQ ID No.: 8)
Tyr-Gln-Lys
Ala-Leu-Asn-Glu-Ile-Asn-Gln-Phe- (SEQ ID No.: 9)
Tyr
Tyr-Leu. (SEQ ID No.: 10)