The invention provides filtration systems and associated methods for filtering a fuel cell reactant stream of particulate and vapor contaminants. In one embodiment, the invention provides a reactant filtration system for a fuel cell, including a first filter having a first inlet and a first outlet, and a second filter having a second inlet and a second outlet. The first filter includes a textile particulate filter, and the second filter includes an activated carbon material. The first and second filters are coupled such that the first inlet is adapted to receive a flow of reactant, which is flowed through the first filter to the first outlet and then to the second inlet, through the second filter and then through the second outlet, which is coupled to an electrode chamber of a fuel cell.