A short interfering RNA (siRNA) duplex that includes complementary sense and anti-sense sequences corresponding to at least part of the A3 adenosine receptor (A3AR) mRNA sequence, a double-stranded RNA (dsRNA) construct that can be converted within a cell into a siRNA duplex and a transcript system that can induce transcription within cells of either a siRNA duplex or a dsRNA construct Also disclosed are a method and a pharmaceutical composition for treating a hyperproliferative disease.