This invention concerns HIV replication inhibitors of formula (I) the
N-oxides, the pharmaceutically acceptable addition salts, the quaternary
amines and the stereochemically isomeric forms thereof, wherein the ring
containing -a.sup.1=a.sup.2-a.sup.3=a.sup.4--and
-b.sup.1=b.sup.2-b.sup.3=b.sup.4represents pheynl, pyridyl, pyrimidinyl,
pirazinyl, pyridazinyl; n is 0 to 5; m is 1 to 4; R.sup.1 is hydrogen;
aryl; formyl; C.sub.1-6alkylcarbonyl; C.sup.1-6alkyl;
C.sub.1-6alkyloxycarbonyl, substituted C.sub.1-6alkyl,
C.sub.1-6alkylcarbonyl; R.sup.2 is hydroxy, halo, optionally substituted
C.sub.1-6alkyl, C.sub.3-7cycloalkyl, optionally substituted
C.sub.2-6alkenyl, optionally substituted C.sub.2-6alkynyl,
C.sub.1-6alkyloxy, C.sub.1-6alkyloxycarbonyl, carboxyl, cyano, nitro,
amino, mono- or di(C.sub.1-6alkyl)amino, polyhalomethyl,
polyhalomethyloxy, polyhalomethylthio, --S(.dbd.O).sub.pR.sup.6,
--NH--S(.dbd.O).sub.pR.sup.6, --C(.dbd.O)R.sup.6, --NHC(.dbd.O)H,
--C(.dbd.O)NHNH?2?, --NHC(.dbd.O)R.sup.6, --C(.dbd.NH)R.sup.6 or a
5-membered hetrocycl; X.sub.1 is --NR.sup.5--, --NH--NH--, --N.dbd.N--,
--O--, --C(.dbd.O)--, C.sub.1-4alkanediyl, --CHOH--, --S--,
--S(.dbd.O).sub.p--, --X.sub.2--C.sub.1-4alkanediyl- or
--C.sub.1-4alkanediyl-X.sub.2--; R.sup.3 is NHR.sup.13,
NR.sup.13R.sup.14; --C(.dbd.O)--NHR.sup.13;
--C(.dbd.O)--NR.sup.13R.sup.14; --C(.dbd.O)--R.sup.15;
--CH.dbd.N--NH--C(.dbd.O)--R.sup.16; substituted C.sub.1-6alkyl;
optionally substituted C.sub.1-6alkyloxyC.sub.1-6alkyl; substituted
C.sub.2-6alkenyl; substituted C.sub.2-6alkynyl; substituted
C.sub.2-6alkylenyl; C.sub.1-6alkyl substituted with hydroxy and a second
substituent; --C(.dbd.N--O--R.sup.8)--C.sub.1-4alkyl; R.sup.7; or
--X.sub.3--R.sup.7; R.sup.4 is halo, hydroxy, C.sub.1-6alkyl,
C.sub.3-7cycloalkyl, C.sub.1-6alkyloxy, cyano, nitro,
polyhaloC.sub.1-6alkyl, polyhaloC.sub.1-6alkyloxy, aminocarbonyl,
C.sub.1-6alkyloxycarbonyl, C.sub.1-6alkylcarbonyl, formyl, amino, mono-
or di(C.sub.1-4alkyl) amino; their use as a medicine, their processes for
preparation and pharmaceutical compositions comprising them ##STR00001##
