A sense amplifier, system and methods for increasing a noise margin of the sense amplifier are contemplated herein. In general, the sense amplifier includes a pair of cascode transistors coupled in parallel between a power supply node and a sense line of the sense amplifier. The sense amplifier also includes a precharge node coupled to the power supply node through a first precharge transistor, and a sense node coupled to the power supply node through a second precharge transistor. The sense amplifier described herein functions to separate the sense node from the precharge node with the pair of cascode transistors, which in turn, increases the noise margin of the sense amplifier by decoupling the sense node from any voltage fluctuations that may be present on the sense line during a sensing state.