A novel class of NIMA interacting proteins (PIN), exemplified by Pin1, is provided. Pin1 induces a G2 arrest and delays NIMA-induced mitosis when overexpressed, and triggers mitotic arrest and DNA fragmentation when depleted. Methods of identifying other Pin proteins and Pin-interacting proteins and identifying compositions which affect Pin activity or expression are also provided.

 
Web www.patentalert.com

< Antibody to bladder cancer nuclear matrix protein and its use

< Synthetic peptides for demyelinating conditions

> Differential tumor cytotoxicity compounds and compositions

> Method of reducing toxicity of retinoids
~ 00298