Various embodiments of a biological interface system and related methods are disclosed. The biological interface system may comprise a sensor comprising a plurality of electrodes for detecting multicellular signals emanating from one or more living cells of a patient, a processing unit configured to receive the multicellular signals from the sensor and process the multicellular signals to produce a processed signal, and a signal gate configured to receive the processed signal from the processing unit and an alternative signal generated by the system, the signal gate being configured to transmit a control signal to a controlled device based on either the processed signal or the alternative signal. A monitoring unit may receive system data and process the system data to produce a system status signal. The system status signal may be used to determine which of the processed signal and the alternative signal is to be used as the control signal.