The present invention is directed to a method for generating a list of package shipment routes in a shipment solution system comprising the steps of entering product information, place of origin, destination and shipment temperature parameters for a package into the system. A list is generated containing a listing of all possible shipment routes available for the package between the place of origin and the destination. For each of the shipment routes, an ambient thermal temperature model is generated corresponding to the external temperatures the package is exposed to during each of the possible shipment routes. The thermal characteristics of the package are calculated along the available shipping routes, based on each of the ambient thermal temperature models, so as to determine feasible shipment routes and corresponding packaging information. For each of the feasible shipment routes, the cost for shipment along the feasible shipment routes is calculated based on packaging and delivery cost and a route is selected for delivery from among the feasible shipment routes.