The disclosure describes techniques for electrical stimulation to regulate the caloric intake of a patient and thereby alleviate obesity. A first set of stimulation pulses is delivered to the stomach to suppress appetite and limit food intake, and a second set of stimulation pulses is delivered to the small intestine to accelerate food transit and reduce caloric absorption. In this manner, the electrical stimulation limits food intake and caloric absorption, providing a two-pronged therapy for obesity. In a sense, the electrical stimulation electrically mimics the physiological effects of the Roux-en-Y gastric bypass procedure without the need for surgery.