A toothpaste dispensing toothbrush includes a toothpaste reservoir in the handle of the toothbrush. A filling port is defined through the aft end of the handle and screw threads are defined on the handle adjacent to the filling port. The screw threads threadably connect to screw threads on the outlet element of a toothpaste tube so the toothpaste tube can be threadably connected to the toothbrush for a filling or a refilling operation.