Various methods are provided, including re-epithelization and wound healing with reduced fibrosis, particularly for the re-epithelization of mucous membrane tissues, most particularly for the treatment and prevention of gum disease and for periodontal regeneration, each of which uses administration of a composition containing one or more rhamnolipids as an active ingredient. The figure provides a graphical representation of the effects of topical BAC-3 on the rate of burn wound closure.