Apparatus and methods for treating obesity using chronic cervical vagal
nerve stimulation (cVNS) of the left vagus trunk are disclosed. Four men
and ten women, average age 46 years (SD.+-.10) were treated with output
current typically 0.75 mA, pulse frequency 30 Hz and width 250 or 500
.mu.s, and duty cycle of 30 s power per five minutes. Mean intake weight
was 91 kg (SD.+-.27, range 46 to 137 kg) with body mass index (BMI) 43
kg/m.sup.2 (SD.+-.5, range 18 to 49 kg/mn.sup.2). After 6-12 months,
obese patients had marked weight loss while normal weights were
maintained. Decrease in BMI was consistently proportional to initial BMI.
Average weight loss at one year was 7 kg (SD.+-.3, range -6 to +24) with
mean drop in BMI of 2 kg/m.sup.2 (SD.+-.3, range -2 to +8)k. All patients
denied any major dieting or exercise.