This present invention is related to an algae fluorescence protein dry powder structure and the manufacturing method thereof. The algae fluorescence protein dry powder structure includes a substrate and a mixture layer, which is coated around the substrate. The mixture layer consists of polysaccharide and algae fluorescence protein, wherein the weight proportion of the polysaccharide should be smaller than 10%. The method will dry the algae fluorescence protein and then protect the structure of them from damage.