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The present invention includes a method for the identification of novel
compounds that interact and stabilize the ligand binding domain of
ERR.gamma., a methodology for producing diffraction quality crystal
structures in the presence of antagonist and agonist ligands and the
identification of novel biologically-active compounds that have an effect
on the transcriptional-activating activity of ERR.gamma..
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> Process for the preparation of (S)-4-fluoromethyl-dihydro-furan-2-one useful in the preparation of the DPP-IV inhibitor (S)-1 ((2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7, 11b-hexahydro-2h-pyrido[2,1-a] isoquinolin-3-yl)-4-fluoromethyl-pyrrolidin-2-one
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~ 00305
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