An injection molding apparatus has at least a nozzle having a nozzle body and a nozzle tip. A securing device is used to secure the nozzle tip to the nozzle body via non-metallic threads or threads having a non-metallic coating that mate with complementary threads on the nozzle body. In this example, through use of the non-metallic threads or threads having a non-metallic coating, the securing device has a longer life than conventional securing devices that were made from steel or titanium by eliminating or substantially reducing thread galling.

 
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> Method of structure-based drug design to create or improve modulators of IL-1 activity which bind to the interleukin-1 type 1 receptor

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