A method, system, and program for sampling responses to communication content for use in analyzing reaction responses to other communications are provided. Responses specified by a user to varying portions of the content of a communication are gathered. These specified responses are then stored in a database according to the types of content responded to, wherein the stored responses are then accessible for use in determining reaction responses by the user in another communication comprising at least one of the types of content. In particular, the communication may include sample content to which a response is requested. Further, the communication may include a proposed communication or a transmitted communication.