Compositions are provided including a synergistic combination of hops isoalpha acids and one or more isoflavones selected from genistein, genistin, daidzein, daidzin, glycitein and glycitin, wherein the weight ratio of hops isoalpha acid extract to isoflavones is from 1:50 to 50:1, calculated as aglucon. These compositions can be used as an anti-inflammatory agent or as a skin agent in particular for anti-ageing purposes.