The invention provides an artificial spinal disc prosthesis that can be implanted to replace a damaged natural spinal disc. The implant includes a synthetic polymer ring. The polymers of the ring are oriented along a common pitch angle relative to a common central axis. Orientation of the polymers provides the ring with added strength and durability. Each synthetic polymer ring further comprises an exterior surface and an interior surface thereby forming a hollow area wherein an additional ring or a nucleus may be enclosed. A pair of angulated prosthetic endplates for use with the implant allow for insertion of the device from a multitude of approaches.

 
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> Antibodies against epitopes with homology to self antigens, methods of preparation

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