A system is configured to selectively block peripheral accesses to system memory. The system includes a secure execution mode (SEM)-capable processor configured to operate in a trusted execution mode. The system also includes a system memory including a plurality of addressable locations. The system further includes a memory controller that may determine a source of an access request to one or more of the plurality of locations of the system memory. The memory controller may further allow the access request to proceed in response to determining that the source of the access request is the SEM-capable processor.