The present invention relates to the field of electrochemical cells and fuel cells, more specifically to polymer-electrolyte-membrane (PEM) fuel cells and describes a process for the manufacture of membrane-electrode-assemblies (MEAs) containing five layers. The five-layer MEA is assembled together by means of a lamination process involving an adhesive component. The anode gas diffusion layer, the catalyst-coated membrane and the cathode gas diffusion layer are combined together by a low temperature/low pressure lamination process. Handling of the MEAs and assembly of the products into PEMFC and DMFC stacks is simplified. Less damage and perforation of the catalyst-coated membrane occurs and thus the performance of the five-layer MEAs is significantly improved.