The present invention provides compounds of formula I: wherein R.sup.1 is
an alkyl, phenyl, heterocyclyl, cycloalkyl, alkoxy, ester, amino or amide
group; R.sup.2 is a phenyl, heterocyclyl, alkyl, cycloalkyl or
cycloalkylalkyl group; R.sup.3 is an alkyl, cycloalkyl, cycloalkylalkyl,
amino or heterocyclyl group; R.sup.4 and R.sup.5 are hydrogen or alkyl
or form a cycloalkyl ring; A is O or N; and m is zero or one; as
inhibitors of GlyT1 and thus as useful for treating or preventing
diseases such as schizophrenia; with the provision of pharmaceutical
compositions, first and second medical uses and methods of treatment.