The preferred methods and devices described herein provide for creating adhesions between the tissue layers of folded soft tissue. The methods described can be accomplished with the use of an endoscope and once folds of tissue are formed and brought together using methods known in the art, the folds can be secured using a clamping system. This clamping system retains the tissue folds in a side by side relationship by exerting a clamping pressure against the folds. Over time the clamping pressure may initiate mucosal layer necrosis, deep tissue layer intermingling and tissue knitting.