Novel multichannel ionosonic devices are described for the treatment of disorders of the skin and nails. In a preferred embodiment, the ionosonic device includes a multichannel ionophoretic driver used in combination with a multichannel dispersion electrode integrated with ultrasonic elements on a single application electrode. The ionosonic device can be configured in a variety of shapes for the treatment of skin disorders through the intradermal delivery of one or more of a variety of therapeutic and modulating agents. The devices described herein deliver the therapeutic agents to the targeted diseased area, obviating the need for systemic ingestion and increasing the therapeutic efficacy for a variety of disorders of the skin and nails thereby sparing the individual from the toxic side effects of the therapeutic agent taken systemically.