An implantable device for use as a tissue graft is disclosed that includes
a substantially decellularized umbilical vessel having a luminal surface
and an ablumenal surface, wherein the substantially decellularized
umbilical vessel is prepared by an automated dissection process. The
substantially decellularized umbilical vessel has not been substantially
cross-linked. In one method of use, the substantially decellularized
umbilical vessel is capable of having at least one cell type seeded at
least a portion of at least one of the luminal and ablumenal surfaces
thereof. Methods of using the implantable device to repair a damaged
tissue are also disclosed.